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| 19:00 | Gremio/RS-BRA | x | Deportivo Riestra-ARG | 64 | 25 | 11 | 1.46 | 3.70 | 8.47 |  | | 19:00 | Sao Paulo/SP-BRA | x | O Higgins-CHI | 71 | 21 | 08 | 1.32 | 4.54 | 10.80 | | | 21:00 | Vasco da Gama/RJ-BRA | x | Audax Italiano-CHI | 68 | 19 | 13 | 1.37 | 4.83 | 7.12 | | | 21:30 | Palestino-CHI | x | City Torque-URU | 42 | 28 | 30 | 2.20 | 3.35 | 3.10 | | | 21:30 | Santos/SP-BRA | x | Deportivo Recoleta-PAR | 73 | 19 | 08 | 1.29 | 4.83 | 11.16 | |
| 19:00 | Caracas FC-VEN | x | Indep Petroleros-BOL | 65 | 23 | 12 | 1.44 | 4.11 | 7.05 | | | 19:00 | Racing Club-ARG | x | Botafogo/RJ-BRA | 51 | 27 | 22 | 1.85 | 3.45 | 4.12 | | | 21:00 | Olimpia-PAR | x | Barracas Central-ARG | 57 | 27 | 16 | 1.63 | 3.49 | 5.66 | | | 21:30 | River Plate-PAR | x | Carabobo-VEN | 78 | 15 | 07 | 1.18 | 6.13 | 13.66 | | | 23:00 | America Cali-COL | x | Alianza Atletico-PER | 67 | 21 | 12 | 1.40 | 4.49 | 7.17 | | | 23:00 | Millonarios-COL | x | Boston River-URU | 68 | 21 | 11 | 1.37 | 4.45 | 8.14 | |
| 19:00 | Atletico/MG-BRA | x | Juventud LP-URU | 72 | 18 | 10 | 1.30 | 5.07 | 9.24 | | | 19:00 | Tigre-ARG | x | Macara-ECU | 60 | 25 | 15 | 1.57 | 3.75 | 5.95 | | | 21:30 | Red Bull Bragantino/SP-BRA | x | Blooming-BOL | 79 | 15 | 06 | 1.18 | 6.29 | 13.84 | | | 21:30 | San Lorenzo-ARG | x | Deportivo Cuenca-ECU | 58 | 29 | 13 | 1.60 | 3.18 | 7.40 | | | 23:00 | Cienciano-PER | x | Puerto Cabello-VEN | 61 | 21 | 18 | 1.52 | 4.33 | 5.33 | |
| 21:30 | Macara-ECU | 1 1x1 1 | America Cali-COL | 27 | 35 | 38 | 3.35 | 2.66 | 2.49 | | | 21:30 | Carabobo-VEN | 1 1x0 0 | Red Bull Bragantino/SP-BRA | 25 | 30 | 45 | 3.75 | 3.15 | 2.15 | | | 19:00 | Juventud LP-URU | 1 1x1 0 | Cienciano-PER | 44 | 28 | 28 | 2.14 | 3.27 | 3.33 | | | 19:00 | Botafogo/RJ-BRA | 0 1x1 1 | Caracas FC-VEN | 75 | 17 | 08 | 1.26 | 5.62 | 10.42 | |
| 23:00 | Puerto Cabello-VEN | 2 2x1 1 | Atletico/MG-BRA | 20 | 29 | 51 | 4.54 | 3.22 | 1.86 | | | 21:30 | City Torque-URU | 0 1x0 0 | Gremio/RS-BRA | 28 | 30 | 42 | 3.39 | 3.08 | 2.22 | | | 21:30 | Blooming-BOL | 0 1x1 1 | River Plate-PAR | 13 | 20 | 67 | 6.95 | 4.69 | 1.39 | | | 21:00 | Audax Italiano-CHI | 0 0x2 2 | Olimpia-PAR | 32 | 33 | 35 | 2.89 | 2.83 | 2.70 | | | 19:00 | Deportivo Cuenca-ECU | 0 1x0 0 | Santos/SP-BRA | 40 | 31 | 29 | 2.37 | 3.04 | 3.14 | | | 19:00 | Deportivo Recoleta-PAR | 1 1x1 1 | San Lorenzo-ARG | 21 | 30 | 49 | 4.44 | 3.10 | 1.91 | | | 19:00 | Deportivo Riestra-ARG | 0 0x0 0 | Palestino-CHI | 50 | 31 | 19 | 1.89 | 3.02 | 4.71 | |
| 23:00 | Alianza Atletico-PER | 0 1x1 1 | Tigre-ARG | 22 | 31 | 47 | 4.23 | 3.06 | 1.98 | | | 21:30 | Boston River-URU | 0 0x1 0 | Sao Paulo/SP-BRA | 16 | 26 | 58 | 5.86 | 3.58 | 1.62 | | | 21:00 | O Higgins-CHI | 1 2x0 0 | Millonarios-COL | 39 | 32 | 29 | 2.43 | 2.97 | 3.12 | | | 19:00 | Indep Petroleros-BOL | 1 1x3 2 | Racing Club-ARG | 17 | 23 | 60 | 5.58 | 4.00 | 1.57 | | | 19:00 | Barracas Central-ARG | 0 0x0 0 | Vasco da Gama/RJ-BRA | 51 | 28 | 21 | 1.85 | 3.31 | 4.44 | |
| 23:00 | Orense-ECU | 0 0x1 0 | Macara-ECU | 48 | 31 | 21 | 1.95 | 3.04 | 4.28 | | | 21:30 | Cienciano-PER | 0 1x1 0 | FBC Melgar-PER | 38 | 28 | 34 | 2.43 | 3.31 | 2.72 | | | 21:30 | America Cali-COL | 1 2x1 1 | Atletico Bucaramanga-COL | 44 | 31 | 25 | 2.12 | 2.97 | 3.75 | | | 19:00 | Nacional Asuncion-PAR | 0 1x1 1 | Deportivo Recoleta-PAR | 52 | 28 | 20 | 1.78 | 3.29 | 4.76 | | | 19:00 | Boston River-URU | 0 1x0 0 | Racing Club-URU | 32 | 32 | 36 | 2.95 | 2.87 | 2.56 | |
| 23:00 | Deportivo Cuenca-ECU | 1 3x0 0 | Libertad-ECU | 53 | 28 | 19 | 1.75 | 3.29 | 5.05 | | | 21:30 | Univ de Chile-CHI | 0 1x2 0 | Palestino-CHI | 58 | 25 | 17 | 1.62 | 3.70 | 5.29 | | | 21:30 | Sportivo Trinidense-PAR | 0 0x1 1 | Olimpia-PAR | 24 | 29 | 47 | 3.85 | 3.22 | 1.97 | | | 21:30 | Atletico Nacional-COL | 1 1x3 2 | Millonarios-COL | 59 | 26 | 15 | 1.58 | 3.60 | 6.21 | | | 19:00 | Caracas FC-VEN | 0 0x0 0 | Metropolitanos-VEN | 42 | 30 | 28 | 2.22 | 3.14 | 3.27 | | | 19:00 | Blooming-BOL | 0 3x0 0 | San Antonio-BOL | 61 | 21 | 18 | 1.52 | 4.46 | 5.17 | |
| 23:00 | Alianza Atletico-PER | 1 2x0 0 | Deportivo Garcilaso-PER | 44 | 31 | 25 | 2.12 | 2.99 | 3.68 | | | 21:30 | Puerto Cabello-VEN | 0 0x0 0 | Monagas-VEN | 48 | 28 | 24 | 1.94 | 3.25 | 3.89 | | | 21:30 | Cobresal-CHI | 0 1x1 1 | Audax Italiano-CHI | 41 | 29 | 30 | 2.27 | 3.22 | 3.06 | | | 19:00 | Indep Petroleros-BOL | 0 0x0 0 | Guabira-BOL | 45 | 26 | 29 | 2.06 | 3.62 | 3.18 | | | 19:00 | City Torque-URU | 0 1x0 0 | Defensor Sporting-URU | 44 | 31 | 25 | 2.12 | 3.00 | 3.68 | |
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