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| 13:45 | AZ Alkmaar | x | NAC Breda | 67 | 20 | 13 | 1.41 | 4.65 | 7.29 |  |
| 14:00 | Leganes | x | Girona | 37 | 31 | 32 | 2.60 | 3.09 | 2.98 | | | 14:00 | Osasuna | x | Sevilla | 41 | 31 | 28 | 2.33 | 3.12 | 3.39 | |
| 15:30 | Club Brugge | x | Union St Gilloise | 50 | 26 | 24 | 1.91 | 3.61 | 3.87 | |
| 16:00 | Twente | x | PSV Eindhoven | 23 | 24 | 53 | 4.04 | 3.97 | 1.79 | |
| 16:30 | Atletico Madrid | x | Rayo Vallecano | 64 | 23 | 13 | 1.49 | 4.19 | 7.19 | | | 16:30 | Betis | x | Valladolid | 80 | 13 | 07 | 1.19 | 7.10 | 14.86 | |
| 19:00 | Bolivar-BOL | x | Palmeiras/SP-BRA | 49 | 27 | 24 | 1.94 | 3.45 | 3.94 | | | 19:00 | Central Cordoba-ARG | x | Deportivo Tachira-VEN | 70 | 20 | 10 | 1.35 | 4.63 | 9.43 | |
| 19:00 | Corinthians/SP-BRA | x | Racing Club-URU | 74 | 16 | 10 | 1.27 | 5.69 | 9.41 | | | 19:00 | Godoy Cruz-ARG | x | Gremio/RS-BRA | 32 | 32 | 36 | 2.89 | 2.92 | 2.64 | |
| 21:00 | Bahia/BA-BRA | x | Atletico Nacional-COL | 55 | 25 | 20 | 1.72 | 3.74 | 4.69 | | | 21:30 | Cerro Porteno-PAR | x | Sporting Cristal-PER | 55 | 25 | 20 | 1.71 | 3.76 | 4.78 | |
| 21:30 | Deportes Iquique-CHI | x | Cienciano-PER | 53 | 26 | 21 | 1.76 | 3.61 | 4.47 | | | 21:30 | Palestino-CHI | x | Cruzeiro/MG-BRA | 25 | 29 | 46 | 3.62 | 3.29 | 2.06 | |
| 21:35 | Novorizontino/SP | x | Athletico/PR | 39 | 30 | 31 | 2.39 | 3.13 | 3.01 | |
| 23:00 | Universidad Catolica-EQU | x | Defensa y Justicia-ARG | 55 | 27 | 18 | 1.70 | 3.53 | 5.11 | |
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