| |  | | | | | | | | 63 | Orenburg | 0x1 | Dinamo Moscow | 3.23 | 3.67 | 2.20 | | | 12:15 | Pari Nizhny | x | Lokomotiv Moscow | 3.70 | 3.53 | 2.00 | |
| | | | | | | | | 13:30 | Hartberg | x | LASK Linz | 3.22 | 3.37 | 2.18 | | | 13:30 | Austria Klagenfurt | x | Salzburg | 7.86 | 4.84 | 1.36 | |
| | | | | | | | | 13:45 | Twente | x | Almere City FC | 1.28 | 5.66 | 10.51 | |
| | | | | | | | | 14:00 | Lorient | x | Paris St Germain | 7.59 | 5.36 | 1.39 | |
| | | | | | | | | 14:30 | Krasnodar | x | Baltika Kaliningrad | 1.70 | 3.79 | 5.11 | | | 14:30 | Zenit St Peterburg | x | Rubin Kazan | 1.34 | 5.06 | 9.34 | |
| | | | | | | | | 15:30 | Rapid Vienna | x | Sturm Graz | 2.87 | 3.31 | 2.41 | |
| | | | | | | | | 15:30 | Club Brugge | x | Racing Genk | 1.74 | 3.89 | 4.49 | | | 15:30 | Anderlecht | x | Cercle Brugge | 1.88 | 3.69 | 3.97 | |
| | | | | | | | | 15:45 | Wolverhampton | x | Bournemouth | 2.79 | 3.60 | 2.51 | | | 16:00 | Crystal Palace | x | Newcastle | 2.77 | 3.75 | 2.45 | | | 16:00 | Everton | x | Liverpool | 7.86 | 5.24 | 1.40 | | | 16:00 | Manchester United | x | Sheffield United | 1.35 | 6.02 | 7.97 | |
| | | | | | | | | 16:00 | Monaco | x | Lille | 2.19 | 3.77 | 3.26 | | | 16:00 | Olympique Marseille | x | Nice | 2.14 | 3.58 | 3.53 | |
| | | | | | | | | 16:00 | Ajax Amsterdam | x | Excelsior SBV | 1.28 | 6.19 | 9.12 | |
| | | | | | | | | 19:00 | Botafogo/RJ-BRA | x | Universitario-PER | 1.44 | 4.27 | 7.18 | | | 19:00 | Huachipato-CHI | x | The Strongest-BOL | 1.66 | 3.95 | 4.65 | | | 19:00 | Nacional-URG | x | Deportivo Tachira-VEN | 1.28 | 5.27 | 10.03 | |
| | | | | | | | | 19:00 | Coquimbo-CHI | x | Racing Club-ARG | 4.26 | 3.56 | 1.82 | | | 19:00 | Danubio-URU | x | Athletico/PR-BRA | 4.01 | 3.30 | 1.92 | | | 21:00 | Bragantino/PA-BRA | x | Sportivo Luqueno-PAR | 1.32 | 4.97 | 8.73 | |
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