| |  | | | | | | | | | 21:00 | Cruzeiro/MG-BRA | x | Universidad Catolica-EQU | 1.50 | 4.05 | 5.70 | |
| | | | | | | | | 07:00 | Sagan Tosu | x | Tokyo FC | 2.86 | 3.34 | 2.43 | |
| | | | | | | | | FT | Independiente del Valle-ECU | 2x1 | Liverpool-URU | 1.23 | 5.82 | 12.20 | | | FT | Palmeiras/SP-BRA | 0x0 | San Lorenzo-ARG | 1.48 | 3.88 | 7.20 | |
| | | | | | | | | FT | Athletico/PR-BRA | 00x10 | Sportivo Ameliano-PAR | 1.19 | 5.98 | 12.63 | | | FT | Danubio-URU | 00x00 | Rayo Zuliano-VEN | 1.10 | 8.11 | 17.36 | |
| | | | | | | | | FT | Libertad-PAR | 2x1 | Nacional-URG | 1.97 | 3.43 | 3.72 | | | FT | River Plate-ARG | 2x0 | Deportivo Tachira-VEN | 1.08 | 11.06 | 21.32 | |
| | | | | | | | | FT | Union La Calera-CHI | 00x10 | Alianza Petrolera-COL | 1.61 | 3.63 | 5.28 | |
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