| |  | | | | | | | | 72 | Osasuna | 1x1 | Mallorca | 2.74 | 3.07 | 2.89 | |
| | | | | | | | | 16:00 | Tottenham | x | Manchester City | 6.92 | 5.74 | 1.40 | |
| | | | | | | | | 16:30 | Real Madrid | x | Alaves | 1.28 | 6.11 | 10.90 | | | 17:00 | Girona | x | Villarreal | 1.81 | 4.36 | 3.91 | |
| | | | | | | | | 19:00 | LDU Quito-ECU | x | Junior-COL | 1.53 | 4.14 | 5.92 | | | 19:00 | Penarol-URU | x | Atletico/MG-BRA | 2.96 | 3.14 | 2.46 | | | 19:00 | Talleres-ARG | x | Cobresal-CHI | 1.22 | 6.19 | 12.82 | |
| | | | | | | | | 19:00 | Racing Club-URU | x | Nacional Asuncion-PAR | 1.78 | 3.46 | 4.49 | |
| | | | | | | | | 19:00 | Avai/SC | x | CRB/AL | 2.40 | 2.98 | 3.19 | | | 19:00 | Vila Nova/GO | x | Novorizontino/SP | 2.32 | 3.05 | 3.27 | |
| | | | | | | | | 21:00 | Defensa y Justicia-ARG | x | Independiente Medellin-COL | 2.08 | 3.30 | 3.45 | | | 21:00 | Sportivo Ameliano-PAR | x | Rayo Zuliano-VEN | 1.07 | 9.27 | 30.73 | |
| | | | | | | | | 21:30 | River Plate-ARG | x | Libertad-PAR | 1.35 | 4.88 | 8.35 | |
| | | | | | | | | 21:30 | Corinthians/SP-BRA | x | Argentinos Juniors-ARG | 1.70 | 3.36 | 5.08 | |
| | | | | | | | | 21:30 | Botafogo/SP | x | Chapecoense/SC | 2.06 | 3.11 | 3.87 | | | 21:30 | Coritiba/PR | x | Guarani/SP | 1.64 | 3.50 | 5.76 | |
| | | | | | | | | 23:00 | Millonarios-COL | x | Palestino-CHI | 1.45 | 4.17 | 7.30 | |
| | | | | | | | | 23:00 | Nacional Potosi-BOL | x | Sportivo Trinidense-PAR | 1.22 | 6.31 | 9.92 | |
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