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| 20:00 | Inter Miami | x | New York City | 63 | 20 | 17 | 1.48 | 4.62 | 5.37 | | | 23:00 | San Diego | x | Vancouver Whitecaps | 41 | 27 | 32 | 2.31 | 3.50 | 2.83 | |
| 00:00 | San Diego | 0 1x0 0 | Minnesota United | 58 | 23 | 19 | 1.62 | 4.12 | 4.86 | |
| 21:45 | Philadelphia Union | 0 0x1 1 | New York City | 50 | 26 | 24 | 1.85 | 3.60 | 3.89 | | | 19:00 | Cincinnati | 0 0x4 1 | Inter Miami | 32 | 25 | 43 | 2.87 | 3.74 | 2.20 | |
| 23:30 | Vancouver Whitecaps | 2 2x2 0 | Los Angeles FC | 44 | 26 | 30 | 2.10 | 3.56 | 3.14 | |
| 23:00 | San Diego | 2 4x0 0 | Portland Timbers | 59 | 21 | 20 | 1.59 | 4.40 | 4.86 | |
| 22:00 | Inter Miami | 2 4x0 0 | Nashville SC | 63 | 20 | 17 | 1.51 | 4.71 | 5.32 | | | 20:00 | Cincinnati | 0 2x1 0 | Columbus | 40 | 26 | 34 | 2.37 | 3.68 | 2.70 | | | 18:00 | Minnesota United | 1 3x3 2 | Seattle | 31 | 27 | 42 | 3.02 | 3.43 | 2.25 | |
| 21:00 | Charlotte | 0 1x3 1 | New York City | 38 | 27 | 35 | 2.45 | 3.37 | 2.66 | |
| 00:45 | Seattle | 3 4x2 2 | Minnesota United | 60 | 22 | 18 | 1.55 | 4.20 | 5.29 | |
| 22:45 | Austin | 1 1x4 3 | Los Angeles FC | 25 | 25 | 50 | 3.75 | 3.68 | 1.87 | | | 20:30 | Columbus | 2 4x0 0 | Cincinnati | 51 | 24 | 25 | 1.83 | 3.91 | 3.64 | |
| 22:30 | Portland Timbers | 1 2x2 1 | San Diego | 37 | 25 | 38 | 2.47 | 3.79 | 2.45 | | | 22:30 | Dallas | 1 1x1 0 | Vancouver Whitecaps | 26 | 24 | 50 | 3.54 | 3.87 | 1.87 | | | 20:30 | Nashville SC | 2 2x1 0 | Inter Miami | 37 | 25 | 38 | 2.50 | 3.72 | 2.47 | | | 18:30 | Chicago | 0 0x3 3 | Philadelphia Union | 44 | 26 | 30 | 2.10 | 3.58 | 3.12 | | | 16:30 | New York City | 0 0x0 0 | Charlotte | 54 | 25 | 21 | 1.72 | 3.75 | 4.36 | |
| 23:30 | Los Angeles FC | 1 2x1 0 | Austin | 68 | 20 | 12 | 1.37 | 4.70 | 7.19 | |
| 19:45 | Charlotte | 0 0x1 1 | New York City | 35 | 27 | 38 | 2.68 | 3.41 | 2.45 | |
| 22:00 | Minnesota United | 0 0x0 0 | Seattle | 32 | 28 | 40 | 2.89 | 3.31 | 2.37 | | | 19:45 | Cincinnati | 0 1x0 0 | Columbus | 39 | 26 | 35 | 2.41 | 3.60 | 2.62 | |
| 22:30 | San Diego | 2 2x1 1 | Portland Timbers | 58 | 22 | 20 | 1.60 | 4.17 | 4.75 | | | 20:30 | Vancouver Whitecaps | 1 3x0 0 | Dallas | 66 | 19 | 15 | 1.42 | 4.91 | 6.03 | | | 18:30 | Philadelphia Union | 0 2x2 0 | Chicago | 51 | 24 | 25 | 1.83 | 3.81 | 3.77 | |
| 21:00 | Inter Miami | 1 3x1 0 | Nashville SC | 61 | 21 | 18 | 1.53 | 4.54 | 5.09 | |
| 23:30 | Portland Timbers | 2 3x1 1 | Real Salt Lake | 44 | 26 | 30 | 2.15 | 3.55 | 3.10 | | | 21:30 | Chicago | 0 3x1 0 | Orlando City | 43 | 26 | 31 | 2.20 | 3.65 | 2.95 | |
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