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| 05:35 | Brisbane Roar | 1 1x0 0 | Melbourne Victory | 35 | 28 | 37 | 2.60 | 3.31 | 2.52 |  |
| 14:00 | Piast Gliwice | 0 0x2 1 | Widzew Lodz | 42 | 29 | 29 | 2.22 | 3.14 | 3.18 | |
| 14:00 | Kocaelispor | 1 1x0 0 | Genclerbirligi | 50 | 28 | 22 | 1.86 | 3.33 | 4.25 | |
| 14:30 | Hannover | 0 3x0 0 | Karlsruher | 65 | 20 | 15 | 1.44 | 4.69 | 5.87 | | | 14:30 | Schalke 04 | 1 2x1 1 | Paderborn 07 | 37 | 30 | 33 | 2.56 | 3.08 | 2.79 | |
| 15:00 | Sonderjyske | 1 2x2 0 | Viborg | 42 | 27 | 31 | 2.22 | 3.43 | 3.00 | |
| 16:30 | Monchengladbach | 0 0x0 0 | RB Leipzig | 32 | 25 | 43 | 2.89 | 3.81 | 2.24 | |
| 16:30 | Radomiak Radom | 2 4x0 0 | Gornik Zabrze | 33 | 29 | 38 | 2.81 | 3.18 | 2.41 | |
| 16:45 | Mechelen | 0 0x1 0 | Standard Liege | 42 | 28 | 30 | 2.24 | 3.29 | 3.10 | |
| 16:45 | Metz | 0 0x1 1 | Rennes | 24 | 25 | 51 | 3.83 | 3.77 | 1.87 | |
| 16:45 | Como | 1 2x0 0 | Sassuolo | 55 | 26 | 19 | 1.71 | 3.66 | 5.00 | |
| 17:00 | Oxford United | 1 2x1 0 | Ipswich Town | 17 | 24 | 59 | 5.54 | 3.91 | 1.59 | |
| 17:00 | Getafe | 1  0 | Elche | 43 | 33 | 24 | 2.20 | 2.87 | 3.93 | |
| 17:15 | Vitoria Guimaraes | 3 4x0 0 | AVS Futebol SAD | 55 | 27 | 18 | 1.71 | 3.50 | 5.00 | |
| 18:30 | Cobresal | 2 3x0 0 | Colo Colo | 30 | 27 | 43 | 3.00 | 3.50 | 2.18 | |
| 19:00 | Juventude/RS | 1 1x1 1 | Bahia/BA | 28 | 28 | 44 | 3.33 | 3.43 | 2.14 | | | 19:30 | Vasco da Gama/RJ | 2 1 | Internacional/RS | 43 | 29 | 28 | 2.22 | 3.20 | 3.33 | |
| 21:00 | LDU Quito | 0 0 | Independiente del Valle | 43 | 28 | 29 | 2.14 | 3.25 | 3.27 | |
| 21:30 | Santos/SP | x | Sport Recife/PE | 72 | 18 | 10 | 1.31 | 5.33 | 9.26 | |
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