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| 19:00 | Independiente del Valle-ECU | x | Liverpool-URU | 76 | 16 | 08 | 1.23 | 5.82 | 12.20 |  | | 19:00 | Palmeiras/SP-BRA | x | San Lorenzo-ARG | 63 | 24 | 13 | 1.48 | 3.88 | 7.20 | |
| 19:00 | Athletico/PR-BRA | x | Sportivo Ameliano-PAR | 78 | 15 | 07 | 1.19 | 5.98 | 12.63 | | | 19:00 | Danubio-URU | x | Rayo Zuliano-VEN | 84 | 11 | 05 | 1.10 | 8.11 | 17.36 | |
| 21:00 | Libertad-PAR | x | Nacional-URG | 48 | 27 | 25 | 1.97 | 3.43 | 3.72 | | | 21:00 | River Plate-ARG | x | Deportivo Tachira-VEN | 87 | 09 | 04 | 1.08 | 11.06 | 21.32 | |
| 21:00 | Cruzeiro/MG-BRA | x | Universidad Catolica-EQU | 61 | 23 | 16 | 1.50 | 4.05 | 5.70 | | | 21:00 | Union La Calera-CHI | x | Alianza Petrolera-COL | 57 | 25 | 18 | 1.61 | 3.63 | 5.28 | |
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