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| 10:00 | Orenburg | x | Dinamo Moscow | 30 | 26 | 44 | 3.23 | 3.67 | 2.20 |  | | 12:15 | Pari Nizhny | x | Lokomotiv Moscow | 25 | 27 | 48 | 3.70 | 3.53 | 2.00 | |
| 13:30 | Austria Klagenfurt | x | Salzburg | 12 | 19 | 69 | 7.86 | 4.84 | 1.36 | | | 13:30 | Hartberg | x | LASK Linz | 29 | 28 | 43 | 3.22 | 3.37 | 2.18 | |
| 13:45 | Twente | x | Almere City FC | 74 | 17 | 09 | 1.28 | 5.66 | 10.51 | |
| 14:00 | Lorient | x | Paris St Germain | 12 | 18 | 70 | 7.59 | 5.36 | 1.39 | |
| 14:30 | Krasnodar | x | Baltika Kaliningrad | 56 | 25 | 19 | 1.70 | 3.79 | 5.11 | | | 14:30 | Zenit St Peterburg | x | Rubin Kazan | 71 | 19 | 10 | 1.34 | 5.06 | 9.34 | |
| 15:30 | Rapid Vienna | x | Sturm Graz | 33 | 28 | 39 | 2.87 | 3.31 | 2.41 | |
| 15:30 | Anderlecht | x | Cercle Brugge | 51 | 26 | 23 | 1.88 | 3.69 | 3.97 | | | 15:30 | Club Brugge | x | Racing Genk | 55 | 24 | 21 | 1.74 | 3.89 | 4.49 | |
| 15:45 | Wolverhampton | x | Bournemouth | 34 | 27 | 39 | 2.79 | 3.60 | 2.51 | | | 16:00 | Crystal Palace | x | Newcastle | 34 | 26 | 40 | 2.77 | 3.75 | 2.45 | | | 16:00 | Everton | x | Liverpool | 13 | 18 | 69 | 7.86 | 5.24 | 1.40 | | | 16:00 | Manchester United | x | Sheffield United | 72 | 16 | 12 | 1.35 | 6.02 | 7.97 | |
| 16:00 | Monaco | x | Lille | 45 | 26 | 29 | 2.19 | 3.77 | 3.26 | | | 16:00 | Olympique Marseille | x | Nice | 46 | 27 | 27 | 2.14 | 3.58 | 3.53 | |
| 16:00 | Ajax Amsterdam | x | Excelsior SBV | 74 | 15 | 11 | 1.28 | 6.19 | 9.12 | |
| 19:00 | Botafogo/RJ-BRA | x | Universitario-PER | 67 | 21 | 12 | 1.41 | 4.54 | 7.55 | | | 19:00 | Huachipato-CHI | x | The Strongest-BOL | 60 | 23 | 17 | 1.59 | 4.08 | 5.47 | | | 19:00 | Nacional-URG | x | Deportivo Tachira-VEN | 72 | 18 | 10 | 1.32 | 5.13 | 9.46 | |
| 19:00 | Coquimbo-CHI | x | Racing Club-ARG | 22 | 26 | 52 | 4.26 | 3.56 | 1.82 | | | 19:00 | Danubio-URU | x | Athletico/PR-BRA | 23 | 28 | 49 | 4.01 | 3.30 | 1.92 | | | 21:00 | Bragantino/PA-BRA | x | Sportivo Luqueno-PAR | 71 | 19 | 10 | 1.32 | 4.97 | 8.73 | |
| 21:30 | Bolivar-BOL | x | Flamengo/RJ-BRA | 40 | 27 | 33 | 2.38 | 3.47 | 2.84 | | | 21:30 | Independiente del Valle-ECU | x | Palmeiras/SP-BRA | 42 | 30 | 28 | 2.27 | 3.18 | 3.38 | | | 21:30 | Libertad-PAR | x | River Plate-ARG | 26 | 26 | 48 | 3.74 | 3.60 | 1.98 | |
| 21:30 | Real Tomayapo-BOL | x | Belgrano-ARG | 16 | 25 | 59 | 5.80 | 3.76 | 1.59 | | | 23:00 | Rayo Zuliano-VEN | x | Sportivo Ameliano-PAR | 28 | 29 | 43 | 3.29 | 3.19 | 2.20 | |
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